Crucible of Science: The Story of the Cori Laboratory - Hardcover

by John H. Exton (Author)

"Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme
catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question.

Author Biography

John H. Exton is Professor of Molecular Physiology and Biophysics at the Vanderbilt University School of Medicine, and Investigator at Howard Hughes Medical Institute.